Los Angeles - Charlize Theron credits Seth MacFarlane for reigniting her love of acting.
The 38-year-old actress admits she was feeling disillusioned with her career until she teamed up with the Family Guy creator for Western comedy A Million Ways to Die in the West, which was also written and directed by Seth.
She said: "I'd gone through like a two-year period where I wasn't really enjoying making movies anymore. And this movie really just shook me and made me realise how much I love it. I owe a lot of that to Seth."
The movie sees Seth portray a cowardly sheep farmer who Charlize's character helps regain his confidence and the Ted star joked their onscreen relationship reflected their real-life bond.
He told the New York Times newspaper: "That wasn't much of a stretch for me. I won't even get on the freeway without my navigator.
"There was a parallel between my personal experience on the movie, for my virgin effort at being on camera, and the story itself.
"As we went along, Charlize was the one person I could quietly turn to, and say, 'Hey, did that seem good to you, or was it too James Brolin?' I don't know why I just said that. He's never done anything to me. Sorry, James Brolin, I think you're great."