The Keeping Up with the Kardashians star, 29, joined forces with several family members in a desperate bid to convince Los Angeles Clippers star Lamar Odom, 33, who was recently accused of cheating on her by two different women, to seek treatment in rehab but the meeting did not go as planned.
A source told gossip website RadarOnline.com: "Lamar has lost a ton of weight in the last few months which triggered a lot of the concern amongst the family.
"Lamar does not want to go to rehab because pre-season training camps are just around the corner.
"He just doesn't care about anyone or anything right now. He has had it with the Kardashians and just wants to be left alone. Everyone is very, very, worried about him."
Is Lamar addicted to hardcore drugs?
Other sources confirmed to TMZ.com that the former LA Lakers star, who has been married to Khloe for four years, has had a problem with "hardcore recreational drugs" for two years and claim he secretly went to rehab in San Diego for three weeks in August 2012.
His reality TV star wife is said to have hired a private investigator to make sure he didn't leave the facility.
One source added: "Khloe is more concerned about saving Lamar than ending her marriage."
Khloe has yet to comment on the allegations but tweeted a message to her fans on Friday, saying: "Your energy is what keeps me going..."
Earlier this week she also posted on Instagram: "NEVER JUDGE SOMEONE WITHOUT KNOWING THE WHOLE STORY. YOU MAY THINK YOU UNDERSTAND BUT YOU DON'T."
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