Los Angeles - Dennis Quaid's wife Kimberly has filed for divorce for a second time.
The couple - who have eight-year-old twins Thomas and Zoe together - are ending their 12-year marriage and insist the split was mutual.
They told TMZ: "After careful consideration, we have decided to end our 12-year marriage. The decision was made amicably and with mutual respect toward one another.
"We will always remain great friends and devoted partners in raising our children."
The pair reportedly plan to share custody of the twins and have already agreed on the division of their assets.
Kimberly first filed for divorce in 2012 but withdrew the filing a few months later when the pair reconciled.
Dennis and Kimberly in a dark place
Thomas and Zoe - who were born via a gestational carrier in November 2007 - were accidentally given a massive overdose of the blood thinner Heparin two weeks after they were born, but Dennis revealed recently that they have experienced no negative effects as they have grown older.
He said: "They're perfectly normal as could be now. They're like head of their class."
However, the Big Easy star admitted he and his wife went to a "dark place" when their kids were fighting for their lives, but always did their best to stay optimistic.
He said: "You go to a dark place. But you gotta pull yourself away from that, you gotta remain optimistic. But everything turned out OK. We had a happy ending."
In December 2008, Dennis and Kimberly reached a $750k settlement with Los Angeles Cedars-Sinai hospital, while the facility was also fined $25k by the California Department of Public Health over the blunder.
The hospital also started taking steps to improve staff training, and the Day After Tomorrow star thinks the terrifying experience brought some "good things".
He explained: "The hospital really stepped up and instituted a lot of patient safety that was very cutting edge and led the way with that.
"So a lot of good things came out of it, and I think a lot of lives got saved because of that ... The drug companies, or the hospitals, actually put my face on the bottle to remind people for a time!
"But you know, it's something that happens to you, you feel strongly about and you step up for it. It was really the kids that went through it and they were the ones that did it."
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