The two-minute film, available on YouTube, is directed by Nowhere Boy filmmaker and artist Sam Taylor-Wood and features the voice of actress Judi Dench in the style of "M", her spymaster character in the Bond movie franchise.
The script asks a besuited Craig-as-Bond a series of questions about issues facing women including pay inequality and domestic violence.
Craig, who is silent throughout, then appears in a long blonde wig, knee-length dress and women's shoes as Dench reads a list of statistics designed to underline the extra hurdles women face in today's society.
"Bond is challenged by 'M' to think about gender inequality, and I hope that the film encourages viewers to do the same," said Taylor-Wood.
"Despite great advances in women's rights, statistics show that when it comes to the balance of power between the sexes, equality is far from being a global reality."
Watch Daniel Craig undergo his dramatic makeover in EQUALS: