The music mogul is heading the production of Thaw with his Crucial Films partner Daniel Schnider.
Thaw - which will be written by Vik Weet - centres around an ancient evil that emerges from the rapidly-melting ice in the Yukon.
Dr Dre launched Crucial Films in 2007 with a first-look deal at New Line to produce a series of dark comedies and horror films and Thaw will be the first under the deal.
Revealed
The movie is the latest venture for Dre as it has been claimed that HTC - the company which has a majority stake in his Beats By Dr Dre headphones range - is in talks to acquire online music service MOG.
He is also still working on the Detox album project, with Rick Ross recently revealing he has joined fellow collaborators Eminem, Snoop Dogg, Jay-Z, 50 Cent and Nas on the record.
Rick Ross said: "We making some things happen, man - we just gonna see where the pieces fall. But we most definitely putting in major work."