Coroner's spokesperson Powell Caesar in Cleveland says an autopsy will be performed. He had no details on the death of the 70-year-old Pekar.
Cleveland Heights police Captain Michael Cannon says officers were called to Pekar's home by his wife about 1:00 on Monday.
Cannon says Pekar had been suffering from prostate cancer, asthma, high blood pressure and depression.
Pekar's American Splendor comics, which he began publishing in 1976, chronicle his grousing about work, money and the monotony of life.