Police were called to the room at about 02:00 and Sheen appeared highly intoxicated, the official said. He was not arrested.
The official spoke to the AP on condition of anonymity. The identity of the woman who was in the hotel room with Sheen is unclear. He was reportedly in New York on a family vacation.
His publicist, Stan Rosenfield, said the 45-year-old actor was expected to be released on Wednesday.
"What we (were) able to determine is that Charlie had an adverse allergic reaction to some medication and was taken to the hospital," he said.
It was the latest in a series of troubles for Sheen, star of the TV show Two and a Half Men, who has had problems with alcohol and drugs in the past.
Anger management
In August, he pleaded guilty to third-degree assault, after an incident on Christmas Day involving his wife, Brooke Mueller.
Prosecutors dropped more serious charges and he avoided prison time. He was sentenced to 30 days in a rehabilitation centre, 30 days of probation and 36 hours of anger management.
Mueller told police that Sheen threatened to kill her and brandished a knife after she told him she wanted a divorce.
Sheen said they had argued but denied threatening her and told police that he was upset by the divorce threat.
In December 1996, he was charged with attacking a girlfriend at his home. He later pleaded no contest and was placed on two years of probation.
In 1998, his father, actor Martin Sheen, turned him in for violating his parole, after a cocaine overdose sent him to the hospital. He was ordered to complete a rehabilitation programme.
He also had a very bitter and public divorce from actor Denise Richards, the mother of his two children, Sam, 6, and Lola, 5.
Sheen has also starred in films such as Platoon, Wall Street and Hot Shots!