The Coachella festival kicks off on Friday and its 75 000 tickets are already sold out.
Die Antwoord will take to the stage on Saturday. Other artists who will be performing at the festival include big names in the music industry, such as Jay Z, Public Image Limited, Vampire Weekend, The Specials, Tiesto, Corinne Bailey Rae, Gossip, Gorillaz, Gary Numan, Yo Le Tango, Florence and the Machines and David Guetta.
Die Antwoord's international break-through came when US-based music website Boing Boing reported on them in February.
Their music video Enter the Ninja is available on their website and on YouTube.
It had over 3 million hits by Wednesday, and their other video, Zefside, had over 1.6 million hits.
Zefside will be shown at the 53rd San Francisco International Film Festival later this month.
Die Antwoord's fan page on Facebook already has over 60 000 members from all over the world, including the US, Canada, Europe, the Ukraine, Russia, the Czech republic, Chile and Sweden.
The New York Times' arts section, as well as publications in France, Brazil, the UK, Taiwan and Belgium, have reported on Die Antwoord. The Enter the Ninja video is even on MTV's playlist in Europe.
Their debut CD, $O$, will be released later this year by Interscope Records, the company which is responsible for, among others, Lady Gaga, U2, Sting, Eminem and the Black Eyed Peas.