Paul Wesley, who plays vampire Stefan Salvatore, is ending his marriage to Torrey DeVitto after two years of marriage. They have no children.
People.com first reported the breakup.
In a statement, DeVitto's publicist Mona Loring says the couple "decided to amicably split" and "they will continue to remain good friends."
DeVitto had a recurring guest spot on the show's third and fourth seasons as a doctor.
She was also a series regular on Lifetime's Army Wives, which just finished its seventh season. She's also a recurring character on ABC Family's Pretty Little Liars.
Wesley and DeVitto met in 2007 on the set of a film.