Los Angeles - Fox's medical drama House is ending its eight-year run this season.
The show's producers, including Emmy-nominated British star Hugh Laurie, said it was a "painful" decision but that the time had come to bring House to a close.
The drama stars Laurie as Dr Gregory House, a brilliant but troubled physician with a gift for unravelling medical mysteries. Omar Epps, Robert Sean Leonard, Jesse Spencer and Charlyne Yi are part of the ensemble cast.
Laurie won two Golden Globes and two Screen Actors Guild Awards for his role.
In a statement made on Wednesday, Laurie and his fellow producers said they imagined Dr House as an "enigmatic creature", and that it was best for him to vanish while there was still mystery in the air.
The season finale date for House, which airs 21:00 EST in the US on Mondays, was not announced.
House made its debut on Fox in November 2004.
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